Avertin or Tribromoethanol
Avertin is a medication that is composed from the substance tribromoethanol and used in lab researches at mice.
It has anesthetic effect. It was manufactured once specifically for use by Winthrop Laboratories and its trade name was Avertin, but this product is no longer avaliable.
Tribromoethanol is suitable for short term procedures in mice and especially surgical ones. It is best used in situations where it will be given only on a single occasion.
It induces anesthesia rapidly and lasts approximately one hour. If it is used appropriately Avertin has a good margin of safety.
Avertin also has many disadvantages such as these:
1) Avertin is an irritant especially at high doses or in repeated use.It is known to create cavity in the abdominal after injections.
2) Avertin degrades in the presence of heat or light and it produces toxic byproducts (nephrotoxic or hepatotoxic) and it can cause death 24h after surgery.
3) Avertin can cause intestinal ileus and death of the animal couple of weeks after use but this happens more often if medication was exposed before usage to heat and light.
4) Avertin also has unpredictable effect in mice that are younger than 16 days and it can produce altered carbohydrate metabolism and diabetes.
The New York Times Crossword Puzzle Dictionary (Puzzles & Games Reference Guides)
Chambers Dictionary, 11th Edition
Miller's Anesthesia: Expert Consult Premium Edition - Enhanced Online Features and Print, 2-Volume Set
Lumb & Jones' Veterinary Anesthesia and Analgesia
Webster's Encyclopedic Unabridged Dictionary of the English Language
Oh's Intensive Care Manual
It has anesthetic effect. It was manufactured once specifically for use by Winthrop Laboratories and its trade name was Avertin, but this product is no longer avaliable.
Tribromoethanol is suitable for short term procedures in mice and especially surgical ones. It is best used in situations where it will be given only on a single occasion.
It induces anesthesia rapidly and lasts approximately one hour. If it is used appropriately Avertin has a good margin of safety.
Avertin also has many disadvantages such as these:
1) Avertin is an irritant especially at high doses or in repeated use.It is known to create cavity in the abdominal after injections.
2) Avertin degrades in the presence of heat or light and it produces toxic byproducts (nephrotoxic or hepatotoxic) and it can cause death 24h after surgery.
3) Avertin can cause intestinal ileus and death of the animal couple of weeks after use but this happens more often if medication was exposed before usage to heat and light.
4) Avertin also has unpredictable effect in mice that are younger than 16 days and it can produce altered carbohydrate metabolism and diabetes.
Resources
Goldfrank's Toxicologic Emergencies (Toxicologic Emergencies (Goldfrank's))The New York Times Crossword Puzzle Dictionary (Puzzles & Games Reference Guides)
Chambers Dictionary, 11th Edition
Miller's Anesthesia: Expert Consult Premium Edition - Enhanced Online Features and Print, 2-Volume Set
Lumb & Jones' Veterinary Anesthesia and Analgesia
Webster's Encyclopedic Unabridged Dictionary of the English Language
Oh's Intensive Care Manual
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